Mosher D F, Williams E M
J Lab Clin Med. 1978 May;91(5):729-35.
Plasma fibronectin (cold-insoluble globulin) is known to be cross-linked to fibrin during the final stage of blood coagulation and is probably the major nonspecific opsonin of blood. We measured the concentration of plasma fibronectin in 36 hospitalized patients (11 with malignancy, 12 with infection, 13 with other underlying diseases) with evidence of fibrin depostion and lysis. Plasma fibronectin concentration was greater than 2 S.D. below the mean of normals in 17 of the patients (p less than 0.001). Depression of fibronectin was not related to severity of disseminated intravascular coagulation, as assessed by fibrinogen concentration and the quantity of FDP in serum. Depressed plasma fibronectin concentration and the quantity of FDP in serum. Depressed plasma fibronectin concentration was an unfavorable prognostic finding, inasmuch as 12 of the 17 patients with depressed fibronectin concentrations died during hospitalization as compared to five of the 19 patients with normal fibronectin concentrations (p less than 0.02). We speculate that specific depletion of plasma fibronectin, because of codeposition with fibrin or due to increased utilization as a nonspecific opsonin, may contribute to the organ failure seen in severely ill patients.
血浆纤连蛋白（冷不溶性球蛋白）已知在血液凝固的最后阶段与纤维蛋白交联，并且可能是血液中的主要非特异性调理素。我们测量了36名住院患者（11名患有恶性肿瘤，12名患有感染，13名患有其他基础疾病）的血浆纤连蛋白浓度，这些患者有纤维蛋白沉积和溶解的证据。17名患者的血浆纤连蛋白浓度比正常均值低2个标准差以上（p小于0.001）。通过纤维蛋白原浓度和血清中FDP的量评估，纤连蛋白的降低与弥散性血管内凝血的严重程度无关。血浆纤连蛋白浓度降低和血清中FDP的量。血浆纤连蛋白浓度降低是一个不利的预后发现，因为在17名纤连蛋白浓度降低的患者中，有12名在住院期间死亡，而在19名纤连蛋白浓度正常的患者中有5名死亡（p小于0.02）。我们推测，由于与纤维蛋白共沉积或作为非特异性调理素的利用率增加，血浆纤连蛋白的特异性消耗可能导致重症患者出现器官衰竭。
