Kubos K L, Moran T H, Robinson R G
Brain Res. 1987 Jan 13;401(1):147-51. doi: 10.1016/0006-8993(87)91174-7.
Sprague-Dawley rats received either unilateral or bilateral electrolytic or 6-hydroxydopamine (6-OHDA) lesions in the nucleus accumbens (n. acc.) and daily spontaneous activity was measured in home cage running wheels for 30 days postoperatively. Bilateral electrolytic lesions increased activity to 230% of preoperative baseline. Right electrolytic lesions produced a 50% increase in activity while left lesion rats were not significantly different from sham-operated controls. Conversely, 6-OHDA lesions depressed activity. Bilateral 6-OHDA lesions had the greatest depressant effect upon activity while unilateral left or right n. acc. treatments produced relatively less hypoactivity. Results support an asymmetrically organized serial inhibition model of spontaneous locomotor control.
将Sprague-Dawley大鼠的伏隔核进行单侧或双侧电解损伤或6-羟基多巴胺（6-OHDA）损伤，并在术后30天在饲养笼的跑轮中测量每日自发活动。双侧电解损伤使活动增加至术前基线的230%。右侧电解损伤使活动增加50%，而左侧损伤大鼠与假手术对照组无显著差异。相反，6-OHDA损伤降低了活动。双侧6-OHDA损伤对活动的抑制作用最大，而单侧左侧或右侧伏隔核治疗产生的活动减少相对较少。结果支持自发运动控制的不对称组织序列抑制模型。
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