Francès H, Diquet B, Goldschmidt P, Simon P
J Neural Transm. 1985;62(1-2):65-76. doi: 10.1007/BF01260416.
The effect in mice of chronic administration of the beta-adrenergic agonist clenbuterol was studied using four pharmacological tests, two of which are predictive of antidepressant activity in man. The suppressive effect of acute administration of the beta-adrenergic agonist in two tests unrelated to antidepressant activity, locomotor activity and investigation of food, was attenuated after chronic treatment. However, in the two tests which are predictive of antidepressant activity, antagonism of reserpine induced hypothermia and potentiation of yohimbine toxicity, the effect of clenbuterol was greater following chronic treatment.
使用四项药理学试验研究了β-肾上腺素能激动剂克伦特罗长期给药对小鼠的影响，其中两项试验可预测其对人类的抗抑郁活性。在与抗抑郁活性无关的两项试验（自发活动和食物探究）中，急性给予β-肾上腺素能激动剂的抑制作用在长期治疗后减弱。然而，在可预测抗抑郁活性的两项试验中，即利血平诱导的体温过低的拮抗作用和育亨宾毒性的增强作用，克伦特罗在长期治疗后的效果更强。
