Dragani T A, Sozzi G, Presutti M
Toxicol Lett. 1983 Jul;17(3-4):215-21. doi: 10.1016/0378-4274(83)90229-1.
A comparative study on hepatic microsomal p-nitroanisole-O-demethylase, aminopyrine-N-demethylase, NADPH-cytochrome c reductase and cytosolic glutathione (GSH) S-transferase was performed in both sexes of C3Hf, C57BL/6J and DBA/2 mice. In control and phenobarbital (PB)-induced mice similarities in hepatic microsomal activities were found with slight variations among strains and sexes. The Ah locus nonresponsive DBA/2 mice showed uninduced microsomal activities after beta-naphthoflavone (BNF), as expected; the other two strains were induced by BNF to a similar extent. Differences in cytosolic GSH S-transferase were detected among strains and sexes; C57BL/6J mice showed the highest basal and induced levels. The males of all the three strains examined were found to have higher GSH S-transferase activity than females.
对C3Hf、C57BL/6J和DBA/2小鼠的雌雄两性进行了肝微粒体对硝基苯甲醚-O-脱甲基酶、氨基比林-N-脱甲基酶、NADPH-细胞色素c还原酶和胞质谷胱甘肽（GSH）S-转移酶的比较研究。在对照和苯巴比妥（PB）诱导的小鼠中，发现肝微粒体活性存在相似性，但品系和性别之间存在细微差异。正如预期的那样，Ah位点无反应的DBA/2小鼠在β-萘黄酮（BNF）处理后显示出未诱导的微粒体活性；其他两个品系被BNF诱导的程度相似。在品系和性别之间检测到胞质GSH S-转移酶存在差异；C57BL/6J小鼠显示出最高的基础水平和诱导水平。在所检测的所有三个品系的雄性中，发现GSH S-转移酶活性均高于雌性。
