Miura Y, Hisaki H, Nagai T, Nagai T
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;85(2):353-5. doi: 10.1016/0742-8413(86)90207-0.
The drug-metabolizing activities (aminopyrine N-demethylase and p-nitroanisole O-demethylase activities) have been measured at monthly intervals throughout the year in liver microsomes of male and female Japanese bullfrogs, Rana catesbeiana. The aminopyrine N-demethylase activity based on cytochrome P-450 of both sexes was significantly higher in May-July (spring-summer) than in August-October (summer-autumn). On the contrary, the p-nitroanisole O-demethylase activity based on cytochrome P-450 of males was significantly higher in July-October (summer-autumn) than in May-June (spring). However, there was no seasonal changes in the O-demethylase activity in females. There were significant differences between males and females in the N-demethylase activity in August-October and in the O-demethylase activity in May-June (or July-October).
全年每月都对日本牛蛙（Rana catesbeiana）雌雄个体肝脏微粒体中的药物代谢活性（氨基比林N - 脱甲基酶和对硝基苯甲醚O - 脱甲基酶活性）进行了测定。基于细胞色素P - 450的两性氨基比林N - 脱甲基酶活性在5月至7月（春夏）显著高于8月至10月（夏秋）。相反，基于细胞色素P - 450的雄性对硝基苯甲醚O - 脱甲基酶活性在7月至10月（夏秋）显著高于5月至6月（春季）。然而，雌性的O - 脱甲基酶活性没有季节性变化。在8月至10月的N - 脱甲基酶活性以及5月至6月（或7月至10月）的O - 脱甲基酶活性方面，雌雄之间存在显著差异。
