Aydin G, Okiye S E, Zincke H
Urol Res. 1983;11(3):105-9. doi: 10.1007/BF00257713.
The effect of 60 min of in situ warm ischaemia (37 degrees C) on renal function was investigated in the rat model. In addition, the effect of pretreatment with intravenously administered furosemide, mannitol, propranolol, methylprednisolone, and adenosine triphosphate-magnesium chloride (ATP-MgCl2), singly or in combination, was studied. The ischaemic kidney was effectively protected by the administration of methylprednisolone alone but not by furosemide, mannitol, ATP-MgCl2, or propranolol singly or in combination. These results demonstrate that rat kidneys subjected to 60 min of warm ischaemia can be safely protected with methylprednisolone pretreatment (3 mg/100 g of body weight) 30 min before warm ischaemia.
在大鼠模型中研究了60分钟原位热缺血（37℃）对肾功能的影响。此外，还研究了单独或联合静脉注射呋塞米、甘露醇、普萘洛尔、甲泼尼龙和三磷酸腺苷-氯化镁（ATP-MgCl2）进行预处理的效果。单独给予甲泼尼龙可有效保护缺血肾脏，而单独或联合使用呋塞米、甘露醇、ATP-MgCl2或普萘洛尔则无此效果。这些结果表明，在热缺血前30分钟用甲泼尼龙预处理（3mg/100g体重）可安全保护经历60分钟热缺血的大鼠肾脏。
