Romodanov A P, Zhmareva E N, Butsenko O I
Zh Vopr Neirokhir Im N N Burdenko. 1983 Jul-Aug(4):11-9.
A marked antitumor effect of the agents studied was demonstrated in experiments on three strains of gliomas of the brain of rats (two rapidly-growing and one slowly-growing tumor). Phthorafur increased the survival of the animals with one of the rapidly-growing tumors (strain No. 35) and often had a marked side effect. Adriablastin inhibited the development of rapidly-growing gliomas but was ineffective in experiments with slowly-growing glioma. NMU considerably increased the survival of the animals in all experiments but recovery was not encountered. In treatment with NMU, a cell population resistant to this agent occurred in the gliomas. A new glioma strain was obtained during the experiments; it was insensitive to therapeutic doses of NMU and differed in morphology from the initial highly-sensitive tumor (strain No. 2211). The prospects of using agents of the nitrosomethyl urea group in the chemotherapy of gliomas are discussed.
在所研究的药物对大鼠脑内三种胶质瘤菌株（两种快速生长型和一种缓慢生长型肿瘤）的实验中，显示出了显著的抗肿瘤作用。呋氟尿嘧啶可提高患有其中一种快速生长型肿瘤（35号菌株）的动物的存活率，但常伴有明显的副作用。阿霉素抑制快速生长型胶质瘤的发展，但在缓慢生长型胶质瘤的实验中无效。N-甲基-N-亚硝基脲在所有实验中均显著提高了动物的存活率，但未观察到恢复情况。在用N-甲基-N-亚硝基脲治疗时，胶质瘤中出现了对该药物耐药的细胞群体。实验期间获得了一种新的胶质瘤菌株；它对N-甲基-N-亚硝基脲的治疗剂量不敏感，且形态与最初高度敏感的肿瘤（2211号菌株）不同。文中讨论了亚硝基甲基脲类药物在胶质瘤化疗中的应用前景。
