Krutova T V, Ostrovskaia L A
Vopr Onkol. 1982;28(11):48-52.
A nitrosomethylurea (NMU)--resistant strain of transplantable solid mammary gland tumor, which arose spontaneously in a F1CBA X S57Bl mouse, was developed, following successive transplantations of tumors from animals which received single intraperitoneal injections of 60-80 mg/kg of NMU. The basic tumor showed a high sensitivity to NMU (4th generation). Resistance to NMU was obtained after the 8th transplantation of tumor from NMU-treated animals: When the treatment of animals with NMU-resistant tumors was continued, tumor growth was stimulated and the time of survival became shorter. Tumors with induced resistance to NMU retained sensitivity to cyclophosphamide and sarcolysin and were refractory to dimethylnitrosourea treatment.
一种可移植性实体乳腺肿瘤的亚硝基甲基脲（NMU）抗性品系，它自发产生于一只F1CBA×S57Bl小鼠，是在对接受单次腹腔注射60 - 80毫克/千克NMU的动物的肿瘤进行连续移植后培育而成的。基础肿瘤对NMU表现出高敏感性（第4代）。在用NMU处理过的动物的肿瘤进行第8次移植后获得了对NMU的抗性：当继续用对NMU有抗性的肿瘤对动物进行处理时，肿瘤生长受到刺激，存活时间缩短。诱导产生对NMU抗性的肿瘤对环磷酰胺和溶肉瘤素仍保持敏感性，对二甲基亚硝基脲处理则不敏感。
