Hagner G, Kölmel H W, Wirthmüller R
Acta Haematol. 1983;70(5):325-9. doi: 10.1159/000206767.
A 40-year-old man with Philadelphia chromosome-positive chronic granulocytic leukaemia developed blast crisis with a mixture of lymphoid and myeloid blasts. A bone marrow relapse with predominantly myeloid features was followed by meningeal leukaemia of purely lymphoid differentiation. The terminal crisis showed a homogenous population of large unclassifiable blasts with simultaneous expression of lymphoid and myelomonocytic surface antigens. The repeated phenotypic conversions were documented by morphological studies and by cell marker analysis with monoclonal antibodies.
一名40岁的费城染色体阳性慢性粒细胞白血病男性患者发生了急变期，伴有淋巴母细胞和髓母细胞混合。以髓系特征为主的骨髓复发后出现了纯淋巴系分化的脑膜白血病。终末期急变显示为一群均一的无法分类的大原始细胞，同时表达淋巴系和髓单核细胞表面抗原。通过形态学研究和单克隆抗体细胞标志物分析记录了多次表型转换。
