Granström G
Acta Odontol Scand. 1983 Aug;41(4):221-6. doi: 10.3109/00016358309162328.
In the microsomal fraction isolated from rat incisor odontoblasts, the influence of several inhibitors on p-nitrophenyl phosphatase activity (p-NPPase) was demonstrated at pH 10.3 and compared with the influence at pH 8.8. The inhibiting effect of EDTA on the p-NPPase activity was reversed by equimolar concentrations of Zn2+. The inhibitory effect of three diphosphonates, ethane-1-hydroxydiphosphonate (EHDP), methanediphosphonate (MDP), and dichloromethanediphosphonate (Cl2MDP) was equal to that of a chelating agent. Tetramisole and levamisole exerted an inhibitory effect that was different from the complexing type. L-Cystein, but not L-ascorbic acid, inhibited p-NPPase activity with a maximum inhibitory effect at pH 10.5.
在从大鼠切牙成牙本质细胞分离出的微粒体部分中，在pH 10.3条件下证明了几种抑制剂对对硝基苯磷酸酶活性（p-NPPase）的影响，并与pH 8.8时的影响进行了比较。等摩尔浓度的Zn2+可逆转EDTA对p-NPPase活性的抑制作用。三种双膦酸盐，即乙烷-1-羟基双膦酸盐（EHDP）、甲撑双膦酸盐（MDP）和二氯甲撑双膦酸盐（Cl2MDP）的抑制作用与螯合剂的抑制作用相当。四咪唑和左旋咪唑产生的抑制作用与络合类型不同。L-半胱氨酸而非L-抗坏血酸可抑制p-NPPase活性，在pH 10.5时具有最大抑制作用。
