Strobl W, Widhalm K, Kostner G, Pollak A
Acta Paediatr Scand. 1983 Jul;72(4):505-9. doi: 10.1111/j.1651-2227.1983.tb09761.x.
The levels of apolipoproteins, A-I, A-II, B and E, lipoprotein (a) and of total cholesterol and triglycerides were determined in cord serum and in capillary serum at the fifth day of life in a group of 44 term newborns. Additionally, cord serum lipoproteins were estimated. Sera from 26 healthy adults were studied for comparison. The concentrations of lipids and lipoproteins in cord serum were diminished as compared to adult levels. The occurrence of lipoprotein (a) in cord serum in concentrations significantly lower than in adults could be established. Serum apolipoproteins A-I, A-II and B were significantly lower at birth than in the adult, whereas apolipoprotein E levels did not differ from adult concentrations. During the first five days apolipoprotein B levels more than doubled, apolipoprotein A-I increased moderately and apolipoprotein E rose slightly. In contrast, serum lipoprotein (a) and apolipoprotein A-II did not change significantly. Unlike serum cholesterol, the levels of apolipoproteins B and E at day five were significantly correlated to those measured at birth in the same infants. The changes of the apolipoprotein pattern during the first week of life reflect the evolution of the lipid transport system of the newborn and may be related to the increasing utilisation of fat and to hormonal factors.
对44名足月新生儿出生时脐带血清和出生后第5天的毛细血管血清中的载脂蛋白A-I、A-II、B和E、脂蛋白(a)以及总胆固醇和甘油三酯水平进行了测定。此外，还对脐带血清脂蛋白进行了评估。研究了26名健康成年人的血清作为对照。与成人水平相比，脐带血清中脂质和脂蛋白的浓度降低。可以确定脐带血清中脂蛋白(a)的浓度明显低于成年人。出生时血清载脂蛋白A-I、A-II和B显著低于成年人，而载脂蛋白E水平与成人浓度无差异。在出生后的前五天，载脂蛋白B水平增加了一倍多，载脂蛋白A-I适度增加，载脂蛋白E略有上升。相比之下，血清脂蛋白(a)和载脂蛋白A-II没有显著变化。与血清胆固醇不同，第5天时载脂蛋白B和E的水平与同一婴儿出生时测得的水平显著相关。出生后第一周载脂蛋白模式的变化反映了新生儿脂质转运系统的演变，可能与脂肪利用增加和激素因素有关。
