脂蛋白（a）浓度作为动脉粥样硬化的风险指标。
Lipoprotein (a) concentrations as risk indicators for atherosclerosis.
作者信息
Kostner G M, Czinner A, Pfeiffer K H, Bihari-Varga M
机构信息
Institute of Medical Biochemistry, University of Graz, Austria.
出版信息
Arch Dis Child. 1991 Sep;66(9):1054-6. doi: 10.1136/adc.66.9.1054.
The plasma concentration of different lipoproteins were measured in 102 control children, in 42 children with a parent suffering from coronary heart disease (CHD), and in 50 children with a parent with cerebrovascular disease (CVD). Significant differences between controls and children in the other two groups were found for apolipoprotein A I, apolipoprotein B, and high density lipoprotein-cholesterol. Children of parents with CHD differed from controls in total cholesterol and apolipoprotein A II concentrations. A highly significant difference furthermore was found in lipoprotein (a) concentrations from children of parents with CHD in comparison with controls, but not between children of parents with CVD and controls. The difference in lipoprotein (a) concentrations (children of parents with CHD compared with controls) were only noticed in children above the age of 10 years. This could be explained by the observed rise of lipoprotein (a) between age 2 and 13 years, which was much more pronounced in the group with parents who had CHD. Plasma glycosaminoglycan concentrations were also measured in the three groups. They were significantly higher in children of parents with CHD and CVD compared with controls; they also varied with age.
对102名对照儿童、42名父母患有冠心病（CHD）的儿童以及50名父母患有脑血管疾病（CVD）的儿童测量了不同脂蛋白的血浆浓度。在载脂蛋白A I、载脂蛋白B和高密度脂蛋白胆固醇方面，发现对照组与其他两组儿童之间存在显著差异。父母患有冠心病的儿童在总胆固醇和载脂蛋白A II浓度方面与对照组不同。此外，与对照组相比，父母患有冠心病的儿童的脂蛋白（a）浓度存在极显著差异，但父母患有脑血管疾病的儿童与对照组之间没有差异。脂蛋白（a）浓度的差异（父母患有冠心病的儿童与对照组相比）仅在10岁以上的儿童中观察到。这可以用2至13岁期间脂蛋白（a）的升高来解释，在父母患有冠心病的组中这种升高更为明显。还测量了三组儿童的血浆糖胺聚糖浓度。与对照组相比，父母患有冠心病和脑血管疾病的儿童的血浆糖胺聚糖浓度显著更高；它们也随年龄而变化。
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