小鼠脑突触体制剂中的次牛磺酸转运

Hypotaurine transport in mouse brain synaptosomal preparations.

作者信息

Kontro P

出版信息

Acta Physiol Scand. 1983 May;118(1):57-60. doi: 10.1111/j.1748-1716.1983.tb07240.x.

DOI:10.1111/j.1748-1716.1983.tb07240.x

Abstract

The transport of hypotaurine, the precursor of the probable neuromodulator taurine, was investigated using mouse brain synaptosomal preparations. Hypotaurine uptake was concentrative, energy- and sodium-dependent and strongly inhibited by GABA, L-DABA (L-2,4-diaminobutyric acid) and beta-alanine, suggesting interactions with GABA uptake systems. The uptake consisted of only one saturable transport component both in adult and in 6-day-old brain, being more efficient in the latter.

摘要

利用小鼠脑突触体标本研究了潜在神经调节剂牛磺酸的前体次牛磺酸的转运。次牛磺酸摄取具有浓缩性、能量依赖性和钠依赖性，且受到γ-氨基丁酸（GABA）、L-2,4-二氨基丁酸（L-DABA）和β-丙氨酸的强烈抑制，这表明其与GABA摄取系统存在相互作用。在成年和6日龄小鼠脑中，摄取均仅由一个可饱和转运成分组成，且在后者中效率更高。