[Plasma lipoproteins and multiple myeloma. Variations of lipid constituents of HDL and apolipoproteins A1 and B].

Patients with myeloma disease showed in general very important abnormalities of circulating lipoproteins. Beside the presence of lipoprotein complexes with abnormal electrophoresis migration, we can observe either an hyperlipidemia associated with antilipoprotein auto-antibodies either, in contrary, an hypolipidemia. We studied 34 myeloma and one alpha heavy chain disease. In these subjects, all presenting clinical and biological myeloma tests but free of hepatic disease we evaluate after HDL separation their major lipid components: cholesterol and phospholipid. By electro immunodiffusion method we evaluate apolipoproteins A1 and B. We observe a decrease of Chol-HDL and PL-HDL in 51 p. cent of cases and a decrease of apo A1 in 80 p. cent of cases, this more marked in myeloma with gamma isotype. In contrary, apo B in all subjects studied remain normal. A correlation test with monoclonal immunoglobulin levels and its isotype is studied; the different parameters of monoclonal disease are discussed in relation with lipoprotein abnormalities.