Ikeuchi T, Onodera Y, Kai Y
Gan To Kagaku Ryoho. 1983 Oct;10(10):2145-51.
A combined chemotherapy of Mitomycin C (20-30 mg) and Cytosine Arabinoside (200 mg) was given intravesical by to 37 patients with superficial bladder tumor. The antitumor effect of the therapy was evaluated as follows. 1) The results were: remarkably effective in 12 cases (32.5%); effective in, 14 cases (37.8%); non-effective in 11 cases (29.7%), with overall rate of 70.3%. 2) The antitumor effect tended to be evident in multiple tumors, small tumors, and tumors of low malignancy. 3) Side effects were found in 35.1% of the cases including 24.3% of bladder irritating symptom. 4) The follow-up period ranged from 12 to 60 months with an average of 36.6 months. Recurrence rate was 27.0%. There was a tendency that recurrence occurred more frequently in cases of multiple tumors and small tumors than in other cases.
对37例浅表性膀胱肿瘤患者进行膀胱内灌注丝裂霉素C（20 - 30毫克）和阿糖胞苷（200毫克）的联合化疗。该疗法的抗肿瘤效果评估如下：1）结果显示：显著有效12例（32.5%）；有效14例（37.8%）；无效11例（29.7%），总有效率为70.3%。2）在多发肿瘤、小肿瘤及低恶性肿瘤中，抗肿瘤效果往往更明显。3）35.1%的病例出现副作用，其中膀胱刺激症状占24.3%。4）随访期为12至60个月，平均36.6个月。复发率为27.0%。多发肿瘤和小肿瘤患者的复发倾向比其他患者更频繁。
