Greenwood R S, Godar S E, Winstead K K
Brain Res Bull. 1983 Jul;11(1):91-101. doi: 10.1016/0361-9230(83)90057-6.
Two types of intracellular activity have been found in neurons in the cortical penicillin seizure focus during an interictal spike; a prolonged depolarization (PDS) followed by hyperpolarization or predominantly hyperpolarization. In the present study of a penicillin focus we have correlated the penicillin focus location with motor behavior and the cellular physiology with cellular morphology and location. Penicillin injection at the same location in the anterior sigmoid gyrus invariably resulted in focal seizures involving the contralateral shoulder. From the locations of the myoclonus and the focus, the character of the movements and the route of seizure spread we conclude that the same pathways mediate movement produced by penicillin seizures or by electrically stimulating the same motor cortex. Intracellular recordings and dye-marking of cells in and around the seizure focus revealed that PDS neurons were located within a 3 mm radius from the site of penicillin injection. All PDS neurons either lacked well filled processes or had abnormal dendrites. Inhibited neurons were all pyramidal neurons with normal dendrites. The dendritic abnormalities observed could be important in the genesis of the PDS.
在发作间期棘波期间，在皮质青霉素癫痫病灶的神经元中发现了两种类型的细胞内活动：先是长时间去极化（PDS），随后是超极化，或者主要是超极化。在本项关于青霉素病灶的研究中，我们将青霉素病灶的位置与运动行为相关联，并将细胞生理学与细胞形态学及位置相关联。在前乙状结肠回的同一位置注射青霉素总是会引发涉及对侧肩部的局灶性癫痫发作。从肌阵挛和病灶的位置、运动特征以及癫痫发作的传播途径来看，我们得出结论，相同的通路介导了由青霉素癫痫发作或通过电刺激相同运动皮层所产生的运动。对癫痫病灶及其周围细胞的细胞内记录和染料标记显示，PDS神经元位于距青霉素注射部位半径3毫米范围内。所有PDS神经元要么缺乏充分填充的突起，要么有异常的树突。观察到的树突异常可能在PDS的发生中起重要作用。
