Ayala G F, Lin S, Vasconetto C
Science. 1970 Feb 27;167(3922):1257-60. doi: 10.1126/science.167.3922.1257.
Penicillin induces partial depolarization and increased excitability of the neuronal membrane of crayfish stretch receptor. Such effects suggest that the epileptic focus created by the topical application of penicillin to the mammalian cerebral cortex may result from the lowering of the threshold for impluse initiation by excitatory synaptic action within the neuron population.
青霉素可诱导小龙虾牵张感受器神经元膜出现部分去极化并增加其兴奋性。这些效应表明，通过向哺乳动物大脑皮层局部应用青霉素所产生的癫痫病灶，可能是由于神经元群体内兴奋性突触作用使冲动起始阈值降低所致。
