Wittmann J, Pruy H
Cell Differ. 1983 Sep;13(1):77-83. doi: 10.1016/0045-6039(83)90080-5.
Xanthine dehydrogenase activity in the liver of embryonic chicks has been shown to be inducible by L-thyroxine, thiourea, and cycloheximide. Results reported here indicate different mechanisms underlying the activation through L-thyroxine on the one hand, and through thiourea and cycloheximide on the other. Using hepatocyte suspension and homogenized liver, it has been shown that prenatal activation of xanthine dehydrogenase results in increased rate of uric acid formation from nucleic acids and purine derivatives, but not from amino acids.
已证明，胚胎期雏鸡肝脏中的黄嘌呤脱氢酶活性可被L-甲状腺素、硫脲和环己酰亚胺诱导。此处报告的结果表明，一方面，L-甲状腺素激活黄嘌呤脱氢酶的机制与另一方面硫脲和环己酰亚胺激活该酶的机制不同。利用肝细胞悬液和肝脏匀浆已表明，黄嘌呤脱氢酶的产前激活导致核酸和嘌呤衍生物而非氨基酸生成尿酸的速率增加。
