Wittmann J, Mengi A, Goldberg M
Enzyme. 1986;35(2):70-6. doi: 10.1159/000469324.
In the experiments reported here, the effect of dexamethasone on hepatic and renal xanthine dehydrogenase toward the end of incubation was studied. Dexamethasone injected on day 17 of incubation into the chick eggs increased the hepatic and decreased the renal activity of xanthine dehydrogenase. Furthermore, dexamethasone was found to accelerate fetal development as measured by the precocious decrease of thymidine uptake into nuclear DNA and by the increased fetus weight/egg weight ratio. The data suggest that an activation of xanthine dehydrogenase is caused by a hatching-independent factor and by a factor related to the hatching process.
在本文报道的实验中，研究了地塞米松在孵育末期对肝和肾黄嘌呤脱氢酶的影响。在孵育第17天给鸡蛋注射地塞米松，可增加肝脏黄嘌呤脱氢酶的活性，降低肾脏黄嘌呤脱氢酶的活性。此外，通过核DNA中胸苷摄取的早熟减少以及胎儿重量/蛋重比的增加来衡量，发现地塞米松可加速胎儿发育。数据表明，黄嘌呤脱氢酶的激活是由与孵化无关的因素和与孵化过程相关的因素引起的。
