Kawasaki H, Murawaki Y, Ohtake H, Hirayama C
Gastroenterol Jpn. 1983 Aug;18(4):314-9. doi: 10.1007/BF02774948.
The purpose of this study was to compare the effect of inhibition of renal prostaglandin synthesis on renal function in 11 patients with alcoholic cirrhosis and 11 with non-alcoholic cirrhosis. After indomethacin administration to the 11 alcoholic patients, the glomerular filtration rate (GFR) and effective renal plasma flow (RPF) decreased significantly (p less than 0.05), but were found to decrease more significantly in the non-alcoholic cirrhosis group. The plasma disappearance rate of indocyanine green was lower in the non-alcoholic group than the alcoholic group, and correlated inversely with the percent decrease in GFR and RPF after indomethacin. These results suggest that the augmented effect of indomethacin is greater in the non-alcoholic group than the alcoholic group, which may be related to the decrease in hepatic blood flow.
本研究的目的是比较抑制肾前列腺素合成对11例酒精性肝硬化患者和11例非酒精性肝硬化患者肾功能的影响。对11例酒精性患者给予吲哚美辛后，肾小球滤过率（GFR）和有效肾血浆流量（RPF）显著降低（p<0.05），但发现非酒精性肝硬化组降低更显著。非酒精性组吲哚菁绿的血浆消失率低于酒精性组，且与吲哚美辛后GFR和RPF的降低百分比呈负相关。这些结果表明，吲哚美辛在非酒精性组中的增强作用大于酒精性组，这可能与肝血流量减少有关。
