Zusman R M, Axelrod L, Tolkoff-Rubin N
Prostaglandins. 1977 May;13(5):819-30. doi: 10.1016/0090-6980(77)90212-x.
Three patients with the hepatorenal syndrome were treated with prostaglandin E1 administered through a selective renal arterial catheter. Prostaglandin E1 was given in progressively increasing doses (2 to 100 ng/kg/min) over a 60-minute period. Control plasma prostaglandin E levels were elevated in all three patients, 0.98, 0.91, and 0.83 ng/ml, respectively. At the end of the infusion, plasma prostaglandin E levels had risen to 10.4, 2.63, and 10.3 ng/ml in the three patients respectively. Plasma renin activity increased during the course of the infusion in two of the patients. The plasma aldosterone concentration did not change during the prostaglandin E1 infusion. Intrarenal prostaglandin E1 failed to increase urine volume or urinary sodium concentration in three patients with the hepatorenal syndrome.
三名肝肾综合征患者通过选择性肾动脉导管给予前列腺素E1进行治疗。前列腺素E1在60分钟内以逐渐增加的剂量（2至100 ng/kg/分钟）给药。三名患者的对照血浆前列腺素E水平均升高，分别为0.98、0.91和0.83 ng/ml。输注结束时，三名患者的血浆前列腺素E水平分别升至10.4、2.63和10.3 ng/ml。两名患者在输注过程中血浆肾素活性增加。在前列腺素E1输注期间，血浆醛固酮浓度未发生变化。肾内前列腺素E1未能增加三名肝肾综合征患者的尿量或尿钠浓度。
