Neu I S, Pelka R B, Fateh-Moghadam A
Fortschr Med. 1983 Sep 22;101(36):1599-604.
In a population comprising 197 patients serum and CSF proteins were assayed using the radial immunodiffusion technique devised by Mancini. Multiple discriminant analysis was applied to investigate whether the measured CSF/serum protein relations and their ratios could be regarded as an indicator of specific neurologic diseases. One significant finding was that the slope angle alpha of the regression line between the serum/CSF relation and molecular weight may represent an important indicative parameter. A small angle is suggestive of enhanced permeability of the blood-brain barrier, a large angle of a correspondingly lowered permeability. Further, the analyses demonstrated that the combined use several predictors can markedly improve differential diagnosis. The study also demonstrates the potential of a statistical analytic technique that is still rarely applied in medicine.
在一个由197名患者组成的群体中，使用曼奇尼设计的放射免疫扩散技术对血清和脑脊液蛋白质进行了检测。应用多元判别分析来研究测得的脑脊液/血清蛋白关系及其比率是否可被视为特定神经系统疾病的指标。一个重要发现是，血清/脑脊液关系与分子量之间回归线的斜率角α可能代表一个重要的指示参数。小角度提示血脑屏障通透性增强，大角度则提示通透性相应降低。此外，分析表明，联合使用多个预测指标可显著改善鉴别诊断。该研究还证明了一种在医学中仍很少应用的统计分析技术的潜力。
