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蜡样芽孢杆菌569突变体中光产物去除的切口后步骤,该突变体产生对紫外线敏感的孢子。

Postincision steps of photoproduct removal in a mutant of Bacillus cereus 569 that produces UV-sensitive spores.

作者信息

Weinberger S, Evenchick Z, Hertman I

出版信息

J Bacteriol. 1983 Nov;156(2):909-13. doi: 10.1128/jb.156.2.909-913.1983.

Abstract

An excision-defective mutant of Bacillus cereus 569 is normal in incision and repair synthesis, but rejoining of incision breaks is defective, resulting in accumulation of low-molecular-weight DNA after UV irradiation. The defect in removal of photoproducts by exonuclease after incision renders both vegetative cells and dormant spores of the mutant sensitive to UV. A similarity is indicated to the uvrD mutation described recently in Escherichia coli.

摘要

蜡样芽孢杆菌569的一个切除缺陷型突变体在切口和修复合成方面正常,但切口断裂的重新连接存在缺陷,导致紫外线照射后低分子量DNA积累。切口后核酸外切酶去除光产物的缺陷使突变体的营养细胞和休眠孢子都对紫外线敏感。这表明与最近在大肠杆菌中描述的uvrD突变有相似之处。

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本文引用的文献

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Enzymology of DNA repair.DNA修复的酶学
IARC Sci Publ. 1980(27):55-73.
5
Effect of the uvrD mutation on excision repair.uvrD突变对切除修复的影响。
J Bacteriol. 1980 May;142(2):535-46. doi: 10.1128/jb.142.2.535-546.1980.
6
Enzymes involved in the repair of damaged DNA.参与受损DNA修复的酶。
Arch Biochem Biophys. 1981 Oct 15;211(2):511-22. doi: 10.1016/0003-9861(81)90485-9.
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DNA repair.DNA修复
Annu Rev Biochem. 1968;37:175-200. doi: 10.1146/annurev.bi.37.070168.001135.

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