Pappius H M, Wolfe L S
J Cereb Blood Flow Metab. 1983 Dec;3(4):448-59. doi: 10.1038/jcbfm.1983.71.
Local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) were studied by autoradiographic techniques in indomethacin- and ibuprofen-treated rats with focal cortical freezing lesions. Widespread depression of LCGU, which developed with time after the lesion in untreated animals was significantly diminished by the prostaglandin synthetase inhibitors indomethacin (single injection 7.5 mg/kg) and ibuprofen (36 mg/kg/day). Both drugs were effective when given 6 h before or up to 24 h after the lesion was made. The effect of the drugs was most striking in cortical areas of the traumatized hemisphere, where the depression was most profound in untreated animals. Thus, 3 days after the lesion, average LCGU in these regions was 46%, 86%, and 98% of normal in untreated, indomethacin-pretreated, and ibuprofen-pretreated rats, respectively. Prostaglandin formation was completely inhibited in the lesion area in the indomethacin-treated rats (PGF2 alpha 1.8 ng/g, compared to 57.5 ng/g in untreated and 1.4 ng/g in nonlesioned animals). The results suggest that some components of the prostaglandin system are involved in mechanisms underlying a widespread depression in functional state of the rat brain that develops in response to injury. In control animals, indomethacin was shown to have a biphasic effect on LCBF, an early depression shown previously by others followed at 24 h by a considerable increase.
采用放射自显影技术，在患有局灶性皮质冷冻损伤的吲哚美辛和布洛芬治疗的大鼠中研究局部脑葡萄糖利用（LCGU）和局部脑血流量（LCBF）。在未治疗的动物中，随着损伤后时间的推移出现的LCGU广泛抑制，被前列腺素合成酶抑制剂吲哚美辛（单次注射7.5 mg/kg）和布洛芬（36 mg/kg/天）显著减轻。两种药物在损伤前6小时或损伤后24小时内给药均有效。药物的作用在受伤半球的皮质区域最为显著，在未治疗的动物中该区域的抑制最为严重。因此，损伤后3天，未治疗、吲哚美辛预处理和布洛芬预处理的大鼠中这些区域的平均LCGU分别为正常水平的46%、86%和98%。在吲哚美辛治疗的大鼠中，损伤区域的前列腺素形成被完全抑制（PGF2α为1.8 ng/g，未治疗动物为57.5 ng/g，未损伤动物为1.4 ng/g）。结果表明，前列腺素系统的某些成分参与了大鼠脑功能状态广泛抑制的机制，这种抑制是对损伤的反应。在对照动物中，吲哚美辛对LCBF有双相作用，早期如其他人先前所示出现抑制，随后在24小时出现显著增加。
