Delitala G, Giusti M, Mazzocchi G, Granziera L, Tarditi W, Giordano G
J Clin Endocrinol Metab. 1983 Dec;57(6):1277-81. doi: 10.1210/jcem-57-6-1277.
To assess the influence of endogenous opioids on human gonadotropin secretion, integrated concentrations of gonadotropins during 24-h naloxone infusion (2.08 mg/h) were examined in a group of six normal men. Naloxone significantly stimulated LH secretion in all subjects, whereas serum FSH levels were similar during both saline and naloxone infusion. Serum testosterone, dihydrotestosterone, and 17 alpha-hydroxyprogesterone levels increased during the infusion of naloxone, but the delta 4-androstenedione concentration was not modified. The frequency and amplitude of LH secretory episodes were clearly increased when an equal amount of the drug was given and LH concentrations were measured every 15 min for 6 h. The results suggest the endogenous opioids inhibit the hypothalamic-pituitary-gonadal axis in normal men.
为评估内源性阿片类物质对人促性腺激素分泌的影响，对一组6名正常男性在静脉输注纳洛酮（2.08毫克/小时）24小时期间的促性腺激素综合浓度进行了检测。纳洛酮在所有受试者中均显著刺激促黄体生成素（LH）分泌，而在输注生理盐水和纳洛酮期间血清促卵泡生成素（FSH）水平相似。在输注纳洛酮期间，血清睾酮、双氢睾酮和17α-羟孕酮水平升高，但Δ4-雄烯二酮浓度未改变。当给予等量药物并每15分钟测量一次LH浓度，持续6小时时，LH分泌脉冲的频率和幅度明显增加。结果提示内源性阿片类物质在正常男性中抑制下丘脑-垂体-性腺轴。
