Barinaga M, Yamonoto G, Rivier C, Vale W, Evans R, Rosenfeld M G
Nature. 1983;306(5938):84-5. doi: 10.1038/306084a0.
Production and release of hormones by the pituitary is known to be under complex hormonal control. Prolactin, for example, is both positively and negatively regulated by steroid and thyroid hormones as well as by peptide hormones. Some hypothalamic releasing factors have been shown to regulate both hormone biosynthesis and hormone release. In the case of growth hormone (GH), glucocorticoids and thyroid hormone stimulate its production, at least in part by stimulating transcription of the GH gene, and somatostatin inhibits and growth hormone-releasing factor (GRF) stimulates its release. So far, however, polypeptide hormone regulation of GH biosynthesis has not been demonstrated. Recently a peptide with GH-releasing activity has been characterized from human pancreatic islet tumours. We report here that pure human pancreatic GRF (hpGRF) stimulates transcription of the GH gene, as well as stimulating GH release.
已知垂体激素的产生和释放受复杂的激素控制。例如，催乳素受到类固醇激素、甲状腺激素以及肽类激素的正向和负向调节。一些下丘脑释放因子已被证明可调节激素的生物合成和释放。就生长激素（GH）而言，糖皮质激素和甲状腺激素至少部分通过刺激GH基因的转录来刺激其产生，而生长抑素抑制其释放，生长激素释放因子（GRF）则刺激其释放。然而，迄今为止，尚未证实多肽激素对GH生物合成的调节作用。最近，从人胰岛肿瘤中鉴定出一种具有GH释放活性的肽。我们在此报告，纯人胰腺GRF（hpGRF）可刺激GH基因的转录，同时也刺激GH的释放。
