Komisar A, Weitz S, Ruben R J
Otolaryngol Head Neck Surg. 1983 Aug;91(4):399-403. doi: 10.1177/019459988309100410.
CSF rhinorrhea can have many causes: traumatic, neoplastic, and iatrogenic origins are common. Most traumatic rhinorrhea ceases after a trial of conservative management. While obvious erosion or traumatic destruction of vital structures may be the underlying cause, other pathophysiologic mechanisms may be working in the formation of CSF rhinorrhea, which may require the combined skills of the otolaryngologist and the neurosurgeon. Leakage of CSF is seen in "high-pressure rhinorrhea," a pathophysiologic state wherein the underlying problem is poor CSF resorption. The result is increased intracranial pressure and eventual rhinorrhea or otorrhea. Areas of CSF leakage correspond to sites of congenital weakness in the cribriform plate region, the parasellar region, or the temporal bone. Weak areas in old base-of-skull fracture sites may leak with increased intracranial pressure. The initial management should stress correction of the deranged pathophysiology, namely shunting. Surgical repair is secondary to controlling the abnormal CSF dynamics.
创伤性、肿瘤性和医源性病因较为常见。大多数创伤性鼻漏经保守治疗试验后会停止。虽然重要结构的明显侵蚀或创伤性破坏可能是根本原因,但其他病理生理机制可能在脑脊液鼻漏的形成中起作用,这可能需要耳鼻喉科医生和神经外科医生的联合技能。脑脊液漏见于“高压性鼻漏”,这是一种病理生理状态,其根本问题是脑脊液吸收不良。结果是颅内压升高,最终导致鼻漏或耳漏。脑脊液漏的区域对应于筛板区域、鞍旁区域或颞骨的先天性薄弱部位。陈旧性颅底骨折部位的薄弱区域可能会在颅内压升高时发生渗漏。初始治疗应强调纠正紊乱的病理生理状态,即分流。手术修复是控制异常脑脊液动力学的次要手段。