Tsan M F
J Nucl Med. 1978 May;19(5):492-5.
The role of polymorphonuclear leukocytes (PMN) and bacteria in the accumulation of gallium-67 in inflammatory lesions was studied using an animal model. A plastic practice golf ball was implanted in the subcutaneous tissue of the abdominal wall of rabbits, and sterile or bacterial inflammation was induced inside the ball. Gallium accumulated in the inflammatory exudates induced by either sterile casein or Staphylococcus aureus. Two rabbits were made agranulocytic by prior treatment with myleran before the injection of S. aureus and gallium. These also accumulated gallium, although in one agranulocytic rabbit there were no PMN in the inflammatory exudate. Analysis of the inflammatory exudates showed that most of the gallium was in the noncellular fraction (2,500-g supernatant) in both sterile and bacteria-induced inflammation. The results indicate that gallium accumulates in the inflammatory lesions, even in the absence of either PMN or bacteria.
使用动物模型研究了多形核白细胞（PMN）和细菌在炎症病变中镓-67蓄积中的作用。将一个塑料练习高尔夫球植入兔腹壁的皮下组织，并在球内诱导无菌或细菌性炎症。镓在无菌酪蛋白或金黄色葡萄球菌诱导的炎性渗出物中蓄积。在注射金黄色葡萄球菌和镓之前，先用白消安对两只兔进行预处理使其粒细胞缺乏。这些兔也蓄积了镓，尽管在一只粒细胞缺乏的兔的炎性渗出物中没有PMN。对炎性渗出物的分析表明，在无菌性和细菌性炎症中，大部分镓都存在于无细胞部分（2500g 上清液）中。结果表明，即使在没有PMN或细菌的情况下，镓也会在炎症病变中蓄积。
