Meltzer H Y, Kolakowska T, Robertson A, Tricou B J
Psychopharmacology (Berl). 1983;81(1):37-41. doi: 10.1007/BF00439271.
Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.
对7名未接受药物治疗的慢性精神分裂症患者和2名分裂情感性障碍患者给予溴隐亭（0.5 - 6.0毫克/天）。4名患者出现短暂轻微改善，另1名患者有显著改善。临床改善与恶心和嗜睡有关。这些剂量的溴隐亭在一些受试者中刺激了血清生长激素并抑制了血清催乳素水平。这些结果表明，溴隐亭可能刺激多巴胺自身受体，并通过这种机制减轻一小部分精神病患者的症状。
