大鼠胃体各层释放前列环素（PGI2）。

Release of prostacyclin (PGI2) by the layers of corpus of rat stomach.

作者信息

Spławińska B, Spławiński J, Corell T, Hasselmann G, Nieszpaur M, Jakubek B

出版信息

Prostaglandins. 1983 Jul;26(1):139-50. doi: 10.1016/0090-6980(83)90081-3.

Abstract

Release of PGI2 by slices of muscularis and mucosa layers of rat corpus stomach was investigated. An anti-aggregatory substance that was released by slices of muscularis was identified as PGI2 in various bioassay systems including anti-serum against PGI2 as well as by stimulation of its generation with AA or PGH2 and by inhibition of this generation with indomethacin or tranylcypromine, respectively. PGI2 was the major PGs released from slices of muscularis. The release of PGI2 from muscularis surpasses a similar release of PGI2 from mucosa by a factor of 10. On the other hand, degradation of exogenous PGI2 was 4 times faster by mucosa than by muscularis slices. Our conclusion is that in the stomach corpus wall of rats, muscularis is the main source of PGI2, which may play a role in regulation of mucosal blood flow.

摘要

对大鼠胃体肌层和黏膜层切片中前列环素（PGI2）的释放情况进行了研究。在各种生物测定系统中，包括使用抗PGI2抗血清，以及分别通过花生四烯酸（AA）或前列环素H2（PGH2）刺激其生成和用吲哚美辛或反苯环丙胺抑制其生成，确定肌层切片释放的一种抗聚集物质为PGI2。PGI2是肌层切片释放的主要前列腺素。肌层中PGI2的释放量比黏膜中PGI2的类似释放量高出10倍。另一方面，黏膜对外源性PGI2的降解速度比对肌层切片快4倍。我们的结论是，在大鼠胃体壁中，肌层是PGI2的主要来源，其可能在黏膜血流调节中发挥作用。