Cifone M G, Alesse E, Ianni G, Reale H, Altamura A, Continenza M A, Conti P
Boll Soc Ital Biol Sper. 1982 Dec 30;58(24):1661-5.
Prostaglandin (PG) E1, PGD2 and the unstable PGI2 are inhibitors of human platelet aggregation and increase the concentration on cAMP in human platelets, presumably by stimulation of the adenylate cyclase. Methylxanthines exert their antiaggregatory effect by inhibiting the platelet cAMP phosphodiesterase. We examined whether caffeine-indomethacin is able to block PGI2 release from gastric mucosa less than the administration of indomethacin alone. PGI2 production was determined on aliquots of incubated mucosal strips, tested for ADP-induced aggregation of human platelet rich plasma. The obtained data indicate that the PGI2 production found in rats treated with the association was higher than that observed in rats treated with indomethacin alone. The present preliminary findings suggest that caffeine when given together with indomethacin reduces the indomethacin-induced inhibition of PGI2 release from the gastric mucosa.
前列腺素（PG）E1、PGD2和不稳定的前列环素（PGI2）是人类血小板聚集的抑制剂，可能通过刺激腺苷酸环化酶来提高人类血小板中cAMP的浓度。甲基黄嘌呤通过抑制血小板cAMP磷酸二酯酶发挥其抗聚集作用。我们研究了咖啡因-吲哚美辛是否比单独使用吲哚美辛更能减少胃黏膜中PGI2的释放。通过对孵育的黏膜条等分试样进行PGI2生成测定，并检测其对富含人血小板血浆中ADP诱导聚集的作用。所得数据表明，联合用药处理的大鼠中发现的PGI2生成量高于单独使用吲哚美辛处理的大鼠。目前的初步研究结果表明，咖啡因与吲哚美辛一起使用时，可减少吲哚美辛诱导的胃黏膜PGI2释放抑制。
