室温下孟加拉玫瑰红的快速放射性碘化
Rapid radioiodination of rose bengal at room temperature.
作者信息
Hupf H B, Wanek P M, O'Brien H A, Holland L M
出版信息
J Nucl Med. 1978 May;19(5):525-9.
Published methods for radioiodination of rose bengal require reaction times of 1 hr or more at temperature from 50 to 120 degrees C. Through the use of an acidified ethanol solvent and potassium iodate oxidant, purified rose bengal is radioiodinated at room temperature within 15 min with chemical yields ranging between 93 and 97%. Radiochemical impurities are sufficiently minimized to permit preparation in a single 10-ml serum vial, requiring no additional purification steps. The method reported here is readily adaptable to cold-kit preparation.
已发表的孟加拉玫瑰红放射性碘化方法要求在50至120摄氏度的温度下反应1小时或更长时间。通过使用酸化乙醇溶剂和碘酸钾氧化剂，纯化的孟加拉玫瑰红在室温下15分钟内即可进行放射性碘化，化学产率在93%至97%之间。放射化学杂质被充分减少，以便在单个10毫升血清瓶中制备，无需额外的纯化步骤。此处报道的方法易于适用于冷试剂盒的制备。
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