Srivastava A K, Singh D P, Chatterjee R K, Ghatak S
Tropenmed Parasitol. 1983 Sep;34(3):174-6.
Activities of certain acid hydrolases (viz. acid phosphatase, beta-glucosidase, beta-galactosidase, N-acetyl-beta-D-glucosaminidase and cathepsine) of post mitochondrial fraction of liver and spleen were studied during the course of Dipetalonema viteae infection in Mastomys natalensis. The values are significantly higher from prepatent to patent phase of infection as compared with normal animals. However, a decrease in the activity of hepatic acid phosphatase and N-acetyl-beta-D-glucosaminidase was noticed in latent phase of infection while a several fold increase in the activity of these enzymes was observed in splenic tissue when there were no detectable microfilariae (mf) in peripheral circulation. The results suggest that lysosomal acid hydrolases which constitute an important component of resistance may be activated by mf products through the sensitized cells of RE system.
在南非多乳鼠感染魏氏双瓣线虫的过程中，对肝脏和脾脏线粒体后组分中某些酸性水解酶（即酸性磷酸酶、β-葡萄糖苷酶、β-半乳糖苷酶、N-乙酰-β-D-葡萄糖胺酶和组织蛋白酶）的活性进行了研究。与正常动物相比，从感染的潜伏期到发病期，这些酶的活性值显著更高。然而，在感染的潜伏期，肝脏酸性磷酸酶和N-乙酰-β-D-葡萄糖胺酶的活性有所下降，而在外周循环中未检测到微丝蚴时，脾脏组织中这些酶的活性却增加了数倍。结果表明，作为抗性重要组成部分的溶酶体酸性水解酶可能通过网状内皮系统的致敏细胞被微丝蚴产物激活。
