Klinte I, Hamberger L, Wiqvist N
Acta Obstet Gynecol Scand. 1983;62(4):303-6. doi: 10.3109/00016348309156226.
Induction of second-trimester abortion was studied by administration of the acridine derivative Rivanol in combination with an i.v. drip infusion of oxytocin or prostaglandin F2 alpha (PG2 alpha), alone or in combination. It was found that an early onset of the i.v. infusion was of major importance for the outcome. Administration of oxytocin in immediate connection with the Rivanol instillation proved more favorable than administration of PGF2 alpha) or a combined oxytocin PGF2 alpha drip, taking into consideration the induction-abortion time as related to the side effects. A lag phase between the instillation of Rivanol and the start of i.v. infusion such as has earlier been frequently recommended seemed to be of no specific advantage, but caused both a prolonged induction-abortion time and an increased incidence of infection.
通过使用吖啶衍生物利凡诺联合静脉滴注催产素或前列腺素F2α（PGF2α）单独或联合使用来研究中期引产。结果发现，静脉滴注的早期开始对引产结果至关重要。考虑到引产时间与副作用的关系，在利凡诺注入后立即给予催产素比给予PGF2α或催产素与PGF2α联合滴注更为有利。利凡诺注入与静脉滴注开始之间的延迟期，如先前经常建议的那样，似乎没有特定优势，反而会导致引产时间延长和感染发生率增加。
