人类大脑中氧气、葡萄糖、二氧化碳和乳酸的运输：数学模型

The transport of oxygen, glucose, carbon dioxide and lactic acid in the human brain: mathematical models.

作者信息

Artigue R S, Bruley D F

出版信息

Adv Exp Med Biol. 1983;159:1-4. doi: 10.1007/978-1-4684-7790-0_1.

Abstract

Mathematical models of the transport of oxygen, glucose, carbon dioxide and lactic acid in the human brain have been developed and solved for both steady-state and dynamic cases which include normal conditions, arterial and venous hypoxia, reduced flow and hematocrit, hypocapnia, reduced glucose and transient arterial upsets. Results indicate that local concentration deficits of oxygen and/or glucose and excesses of lactic acid can exist within the system described by the models and therefore possibly could exist in the tissues of the human brain under similar conditions.

摘要

已经建立了人体大脑中氧气、葡萄糖、二氧化碳和乳酸传输的数学模型，并针对稳态和动态情况进行了求解，这些情况包括正常条件、动脉和静脉缺氧、血流量和血细胞比容降低、低碳酸血症、葡萄糖减少以及短暂的动脉紊乱。结果表明，在模型所描述的系统中可能存在氧气和/或葡萄糖的局部浓度不足以及乳酸过量的情况，因此在类似条件下人体大脑组织中也可能存在这种情况。