通过免疫反应性蛋白和凝血酶可凝蛋白的平行测定法检测脐带血浆中的人胎儿纤维蛋白原。
Detection of human fetal fibrinogen in umbilical cord plasma by parallel assays of immunoreactive and thrombin-clottable protein.
作者信息
Barr R D, Storbeck M M, Johnston M A, Horsewood P, Gauldie J
出版信息
Ann Clin Res. 1983 Jun;15(3):104-8.
PMID:6416136
Abstract
Putative fetal fibrinogen was detected in normal human umbilical cord plasma by parallel assays of immunoreactive and thrombin-clottable protein. The 'excess' of immunoassayable fibrinogen was not due to products of proteolysis and the apparent 'insensitivity' to thrombin was reflected in delayed fibrin polymerization. Fetal fibrinogen was partially separable from the adult protein by two-dimensional immunoelectrophoresis.
摘要
通过对免疫反应性蛋白和凝血酶可凝固蛋白的平行检测，在正常人脐带血浆中检测到了假定的胎儿纤维蛋白原。免疫分析法检测到的纤维蛋白原“过量”并非由蛋白水解产物导致，而对凝血酶的明显“不敏感性”体现在纤维蛋白聚合延迟上。通过二维免疫电泳，胎儿纤维蛋白原可与成人纤维蛋白原部分分离。
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