多胺生物合成抑制剂与丝裂霉素C联合抗肿瘤治疗

[Combined antitumor therapy with polyamine biosynthesis inhibitors and mitomycin C].

作者信息

Fujimoto S, Shrestha R D, Miyazaki M, Ohyama Y, Endoh F, Shimura T, Takahashi O, Sugasawa H, Okui K, Igarashi K

出版信息

Gan To Kagaku Ryoho. 1983 Nov;10(11):2347-52.

Abstract

A combined effect of the polyamine biosynthesis inhibitors, alpha-difluoromethylornithine (DFMO) and methyglyoxal-bis-guanylhydrazone (MGBG) with mitomycin C (MMC) was studied. DFMO, MGBG and MMC were given intraperitoneally to nude mice xenotransplanted human gastric cancer. This new combination of the three drugs resulted in the complete halt of the xenotransplanted tumor growth and marked decline of spermine levels in the tumor tissues. The other treatments with DFMO and MGBG as well as MMC alone were inferior to this new combined therapy in suppression in both tumor growth and tissue spermine level. These data suggest that this new combined treatment be effective against human gastric cancer.

摘要

研究了多胺生物合成抑制剂α-二氟甲基鸟氨酸（DFMO）和甲基乙二醛双脒腙（MGBG）与丝裂霉素C（MMC）的联合作用。将DFMO、MGBG和MMC腹腔注射给异种移植人胃癌的裸鼠。这三种药物的新组合导致异种移植肿瘤生长完全停止，肿瘤组织中精胺水平显著下降。单独使用DFMO和MGBG以及MMC的其他治疗方法在抑制肿瘤生长和组织精胺水平方面均不如这种新的联合疗法。这些数据表明这种新的联合治疗对人类胃癌有效。

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