Fujimoto S, Shrestha R D, Igarashi K, Terao K, Hirose S, Okui K
Gan To Kagaku Ryoho. 1982 Oct;9(10):1778-84.
The polyamine synthesis inhibitors--alpha-difluoromethylornithine (DFMO) and methylglyoxal bis (guanylhydrazone) (MGBG)--were put to antitumor tests based on the premise of treatment for human gastrointestinal cancer. The both drugs were administered intraperitoneally to BALB/c nude mice xenoplanted human gastric cancer for 10 consecutive days. Both marked antitumor effects and side effects were observed in mice treated at the dosage of DFMO 500 mg/kg/day and/or MGBG 50 mg/kg/day and/or MGBG 30 mg/kg/day brought about significant antitumor effects as well as less side effects. Microscopic observation revealed antitumor actions of these drugs as cytostatic rather than cytocidal. Tumor regrowth after the termination of this combined treatment, however, was noticed. Judging from these data, the both drugs may be effective against human gastrointestinal cancer with minor side effects.
基于对人类胃肠道癌的治疗前提，对多胺合成抑制剂——α-二氟甲基鸟氨酸（DFMO）和甲基乙二醛双（脒腙）（MGBG）进行了抗肿瘤试验。将这两种药物连续10天腹腔注射给接种了人胃癌的BALB/c裸鼠。在以500mg/kg/天的DFMO和/或50mg/kg/天的MGBG和/或30mg/kg/天的MGBG剂量治疗的小鼠中观察到了显著的抗肿瘤作用和副作用，同时也产生了显著的抗肿瘤作用且副作用较小。显微镜观察显示这些药物的抗肿瘤作用是抑制细胞生长而非杀灭细胞。然而，在这种联合治疗终止后观察到肿瘤复发。从这些数据判断，这两种药物可能对人类胃肠道癌有效且副作用较小。
