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1
Endotoxaemia in cystic fibrosis: response to antibiotics.囊性纤维化中的内毒素血症:对抗生素的反应
Arch Dis Child. 1983 Oct;58(10):826-8. doi: 10.1136/adc.58.10.826.
2
Tobramycin and carbenicillin compared with gentamicin and carbenicillin in the treatment of infection with Pseudomonas aeruginosa in adult patients with cystic fibrosis.妥布霉素和羧苄西林与庆大霉素和羧苄西林治疗成年囊性纤维化患者铜绿假单胞菌感染的比较。
Br J Dis Chest. 1983 Jan;77(1):71-7.
3
Gentamicin and tobramycin compared in the treatment of mucoid pseudomonas lung infections in cystic fibrosis.庆大霉素与妥布霉素治疗囊性纤维化患者黏液型铜绿假单胞菌肺部感染的比较
Arch Dis Child. 1980 Aug;55(8):604-7. doi: 10.1136/adc.55.8.604.
4
Antibiotic treatment of chronic Pseudomonas aeruginosa infection in cystic fibrosis patients.囊性纤维化患者慢性铜绿假单胞菌感染的抗生素治疗
Scand J Infect Dis Suppl. 1981;29:87-91.
5
The fecal microflora and bile acids in children with cystic fibrosis.囊性纤维化患儿的粪便微生物群和胆汁酸
Am J Clin Nutr. 1979 Dec;32(12):2404-9. doi: 10.1093/ajcn/32.12.2404.
6
[Anti-Pseudomonas aerosol therapy in cystic fibrosis: improvement with tobramycin].[囊性纤维化中的抗假单胞菌雾化治疗:妥布霉素的疗效改善]
Rev Pneumol Clin. 2002 Jun;58(3 Pt 1):131-8.
7
Pseudomonas aeruginosa in cystic fibrosis patients with c.1652G›A (G551D)-CFTR treated with ivacaftor-Changes in microbiological parameters.接受依伐卡托治疗的携带c.1652G›A(G551D)-CFTR的囊性纤维化患者中的铜绿假单胞菌——微生物学参数的变化
J Clin Pharm Ther. 2018 Feb;43(1):92-100. doi: 10.1111/jcpt.12616. Epub 2017 Sep 22.
8
The management of cystic fibrosis. Observations on gentamycin when used with other antibiotics in pulmonary infections associated with cystic fibrosis.囊性纤维化的管理。关于庆大霉素与其他抗生素联合用于囊性纤维化相关肺部感染时的观察。
Clin Pediatr (Phila). 1975 Dec;14(12):1115-8.
9
Antibiotic therapy and cystic fibrosis: increased resistance of mucoid Pseudomonas aeruginosa to carbenicillin.抗生素治疗与囊性纤维化:黏液型铜绿假单胞菌对羧苄西林耐药性增加。
J Antimicrob Chemother. 1976 Jun;2(2):215-7. doi: 10.1093/jac/2.2.215.
10
Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa.
Br J Dis Chest. 1987 Jul;81(3):272-9. doi: 10.1016/0007-0971(87)90161-6.

引用本文的文献

1
Chemokine receptor and ligand upregulation in the diaphragm during endotoxemia and Pseudomonas lung infection.内毒素血症和铜绿假单胞菌肺部感染期间膈肌中趋化因子受体和配体的上调
Mediators Inflamm. 2009;2009:860565. doi: 10.1155/2009/860565. Epub 2009 Apr 29.
2
Endotoxemia: methods of detection and clinical correlates.内毒素血症:检测方法及临床关联
Clin Microbiol Rev. 1995 Apr;8(2):268-92. doi: 10.1128/CMR.8.2.268.

本文引用的文献

1
Is anti-Pseudomonas therapy warranted in acute respiratory exacerbations in children with cystic fibrosis?囊性纤维化患儿急性呼吸道加重期是否需要进行抗假单胞菌治疗?
J Pediatr. 1980 Jul;97(1):144-7. doi: 10.1016/s0022-3476(80)80155-7.
2
Principles of a quantitative assay for bacterial endotoxins in blood that uses Limulus lysate and a chromogenic substrate.一种使用鲎试剂和显色底物对血液中细菌内毒素进行定量测定的方法的原理。
J Clin Microbiol. 1980 Nov;12(5):644-50. doi: 10.1128/jcm.12.5.644-650.1980.
3
Detection of proximal-vein thrombosis by Doppler ultrasound flow-detection method.采用多普勒超声血流检测法检测近端静脉血栓形成。
Lancet. 1972 Jan 1;1(7740):1-4. doi: 10.1016/s0140-6736(72)90001-3.
4
Bacterial endotoxins. The second Carl Prausnitz Memorial Lecture.细菌内毒素。第二届卡尔·普劳斯尼茨纪念讲座。
Int Arch Allergy Appl Immunol. 1975;49(1-2):1-43.
5
Portal venous and systemic endotoxaemia in patients without liver disease and systemic endotoxaemia in patients with cirrhosis.无肝脏疾病患者的门静脉和全身内毒素血症以及肝硬化患者的全身内毒素血症。
Scand J Gastroenterol. 1976;11(8):857-63.

囊性纤维化中的内毒素血症:对抗生素的反应

Endotoxaemia in cystic fibrosis: response to antibiotics.

作者信息

Taylor G, Stern C, Silverman M, Mearns M

出版信息

Arch Dis Child. 1983 Oct;58(10):826-8. doi: 10.1136/adc.58.10.826.

DOI:10.1136/adc.58.10.826
PMID:6416186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1628287/
Abstract

In a study of 6 children with cystic fibrosis receiving intravenous antibiotics for pseudomonas lung infection, serum endotoxin values were monitored by a modification of the limulus lysate technique. The values fell with treatment, reflecting a response that was not always apparent on clinical assessment. Endotoxin concentrations may offer a more precise way of monitoring the effects of antibiotic treatment in CF patients.

摘要

在一项针对6名患有囊性纤维化且因铜绿假单胞菌肺部感染接受静脉抗生素治疗的儿童的研究中,通过改良的鲎试剂法监测血清内毒素值。这些值随着治疗而下降,这反映出一种在临床评估中并不总是明显的反应。内毒素浓度可能为监测囊性纤维化患者抗生素治疗效果提供一种更精确的方法。