Rowan A J, Meijer J W, de Beer-Pawlikowski N, van der Geest P, Meinardi H
Arch Neurol. 1983 Dec;40(13):797-802. doi: 10.1001/archneur.1983.04050120047006.
Five patients had absence seizures refractory to treatment with either ethosuximide or valproate sodium. To determine their response to combination therapy with the two drugs, four of the five had serial 24-hour intensive monitoring studies that included cable telemetric EEG recording, closed-circuit television observation, and frequent antiepileptic drug (AED) serum level determinations. The resultant data confirmed the clinical and EEG effects of serial alterations in AED programs. All five became seizure free with combination therapy. Combination therapy with ethosuximide and valproate should be considered in patients whose absence seizures do not respond to standard therapeutic measures.
五名患者患有失神发作，使用乙琥胺或丙戊酸钠治疗均无效。为了确定他们对这两种药物联合治疗的反应，五名患者中的四名进行了连续24小时的强化监测研究，包括有线遥测脑电图记录、闭路电视观察以及频繁测定抗癫痫药物（AED）的血清水平。所得数据证实了AED方案连续改变的临床和脑电图效果。所有五名患者联合治疗后均无癫痫发作。对于失神发作对标准治疗措施无反应的患者，应考虑乙琥胺和丙戊酸联合治疗。
