Frisman D, Slovin S, Royston I, Baird S
Blood. 1983 Dec;62(6):1224-9.
We describe a monoclonal antibody that reacts with human B-lymphoid cells. We have characterized the reactions of this antibody on normal blood lymphocytes, with and without pokeweed mitogen stimulation, bone marrow lymphocytes, and on frozen sections of normal lymph nodes. The antibody, B532, appears to recognize an activation antigen on human B cells. This activation antigen can apparently be induced both by infection with Epstein-Barr virus and by stimulation with antigens and mitogens, but it is lost on plasma cells. In normal lymph nodes, the antigen is confined to germinal center cells and some of the cells of the "mantle" that surrounds germinal centers. The antigen is not present on T cells.
我们描述了一种与人类B淋巴细胞发生反应的单克隆抗体。我们已对该抗体在有或无商陆有丝分裂原刺激的正常血液淋巴细胞、骨髓淋巴细胞以及正常淋巴结冰冻切片上的反应进行了表征。抗体B532似乎识别出人类B细胞上的一种活化抗原。这种活化抗原显然可由爱泼斯坦-巴尔病毒感染以及抗原和有丝分裂原刺激诱导产生，但在浆细胞上会消失。在正常淋巴结中，该抗原局限于生发中心细胞以及围绕生发中心的“套膜”中的一些细胞。T细胞上不存在该抗原。
