Anderson J R, Johnston G W
Br Med J (Clin Res Ed). 1983 Dec 3;287(6406):1657-8. doi: 10.1136/bmj.287.6406.1657.
Five patients given vasopressin by infusion to reduce portal hypertension developed signs of cutaneous gangrene 18-24 hours after the start of the infusion. Four patients were treated by application of local dressings; in three cases the lesions healed, but the fourth patient died from variceal haemorrhage. The remaining patient required split skin grafting but died 48 hours after operation. The mechanism of this effect of vasopressin is not clear, but if local blanching of the skin is noted during infusion the catheter should be flushed immediately with a vasodilator in an effort to counteract the drug's vasoconstrictor effect.
5例为降低门静脉高压而输注加压素的患者在输注开始后18 - 24小时出现皮肤坏疽迹象。4例患者接受了局部敷料治疗；3例患者的病变愈合，但第4例患者死于静脉曲张出血。其余1例患者需要进行植皮手术，但术后48小时死亡。加压素产生这种作用的机制尚不清楚，但如果在输注过程中发现皮肤局部变白，应立即用血管扩张剂冲洗导管，以抵消药物的血管收缩作用。
