Mogan G R, Wormser G P, Gottfried E B
Am J Gastroenterol. 1980 May;73(5):426-9.
Vasopressin (Pitressin) infusion through peripheral veins is a commonly used modality for control of bleeding esophageal varices. In this report we describe the development of infected gangrene at the site of accidental vasopressin infiltration in a patient with diabetes mellitus, cirrhosis and bleeding esophageal varices. Among the explanations for the development of gangrene are: 1. continuous intravenous administration; 2. diabetic peripheral vascular disease; 3. mechanical compression of extravasated fluid in a closed space. No antagonist has been clinically proven to reverse the vasoconstrictive effects of vasopressin.
通过外周静脉输注血管加压素（垂体后叶素）是控制食管静脉曲张出血常用的方法。在本报告中，我们描述了一名患有糖尿病、肝硬化和食管静脉曲张出血的患者，在血管加压素意外渗漏部位发生感染性坏疽的情况。坏疽发生的原因包括：1. 持续静脉给药；2. 糖尿病周围血管疾病；3. 封闭空间内渗出液的机械压迫。目前尚无临床证实的拮抗剂可逆转血管加压素的血管收缩作用。
