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过氧化氢作为体外哺乳动物中枢神经系统制剂的分子氧来源。

Hydrogen peroxide as a source of molecular oxygen for in vitro mammalian CNS preparations.

作者信息

Walton K, Fulton B

出版信息

Brain Res. 1983 Nov 14;278(1-2):387-93. doi: 10.1016/0006-8993(83)90280-9.

DOI:10.1016/0006-8993(83)90280-9
PMID:6416610
Abstract

Using an isolated neonatal rat spinal cord preparation, we have studied the ability of hydrogen peroxide to act as a source of oxygen for mammalian central nervous system (CNS) maintained in vitro. We report here that hydrogen peroxide, in low concentrations (0.001-0.004%), can effectively provide the only source, or act as a supplementary source of oxygen. This is brought about via the intracellular enzyme catalase which catalyzes the conversion of H2O2 into molecular oxygen and water.

摘要

利用离体新生大鼠脊髓制备物，我们研究了过氧化氢作为体外维持的哺乳动物中枢神经系统（CNS）氧气来源的能力。我们在此报告，低浓度（0.001 - 0.004%）的过氧化氢能够有效地提供唯一的氧气来源，或作为氧气的补充来源。这是通过细胞内酶过氧化氢酶实现的，该酶催化过氧化氢转化为分子氧和水。

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