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[磷酸肌酸对正常脊髓及缺氧状态下反射传导的影响]

[The effect of creatine phosphate on reflex transmission in the normal spinal cord and under hypoxic conditions].

作者信息

Limanskiĭ Iu P, Tamarova Z A, Piliavskiĭ A I, Oksamitnyĭ V N, Khasabov S G, Bulgakova N V

出版信息

Zh Vopr Neirokhir Im N N Burdenko. 1990 Jul-Aug(4):25-8.

PMID:2173305
Abstract

The effect of phosphocreatine on reflex transmission in the spinal cord was studied in rats in vivo and in vitro. Low concentrations (10(-8)-10(-6) M) of phosphocreatine facilitated while high concentrations (10(-4)-10(-3) M) inhibited the amplitude of mono- and polysynaptic reflexes. It was found that phosphocreatine decreases the inhibiting action of hypoxia on test responses and accelerates restoration of the reflex transmission in the spinal cord.

摘要

在体内和体外对大鼠研究了磷酸肌酸对脊髓反射传递的影响。低浓度(10^(-8)-10^(-6)M)的磷酸肌酸促进单突触和多突触反射的幅度,而高浓度(10^(-4)-10^(-3)M)则抑制其幅度。发现磷酸肌酸可降低缺氧对测试反应的抑制作用,并加速脊髓反射传递的恢复。

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