Severson J A, Randall P K
Brain Res. 1983 Nov 21;279(1-2):295-8. doi: 10.1016/0006-8993(83)90196-8.
The anatomic localization of specific striatal [3H]N-propylnorapomorphine ( [3H]PNA) binding was determined in male C57BL/6J mice. Striatal [3H]PNA binding was high affinity and sensitive to guanine nucleotides. Frontal cortical ablation did not alter striatal [3H]PNA binding, but reduced [3H]spiperone binding by 36%. Kainic acid reduced and 6-hydroxydopamine elevated [3H]PNA binding. A combined frontal cortical ablation and striatal kainic acid lesion was similar to that of kainate alone. These data are consistent with a localization of [3H]PNA binding sites on neurons intrinsic to the mouse striatum.
在雄性C57BL/6J小鼠中确定了特定纹状体[3H]N-丙基去甲阿朴吗啡（[3H]PNA）结合的解剖定位。纹状体[3H]PNA结合具有高亲和力且对鸟嘌呤核苷酸敏感。额叶皮质切除未改变纹状体[3H]PNA结合，但使[3H]螺哌隆结合减少了36%。 kainic酸降低而6-羟基多巴胺升高了[3H]PNA结合。额叶皮质切除和纹状体kainic酸损伤联合作用与单独使用kainate相似。这些数据与[3H]PNA结合位点定位于小鼠纹状体内的神经元一致。
