短期碳酸锂对II型糖尿病的影响。

The effect of short term lithium carbonate in Type II diabetes mellitus.

作者信息

Jones G R, Lazarus J H, Davies C J, Greenwood R H

出版信息

Horm Metab Res. 1983 Sep;15(9):422-4. doi: 10.1055/s-2007-1018745.

DOI:10.1055/s-2007-1018745

Abstract

The metabolic response to a standard 50 g carbohydrate breakfast was evaluated over 3 hours in 6 Type II maturity onset diabetic patients before and after 1 week of lithium carbonate administration (serum Lithium 0.5-1.5 mmol/l). Plasma glucose response was significantly less after lithium between 60 and 180 minutes but plasma insulin did not change. Insulin/glucose ratios fell by 17.3% at 60 minutes and rose by 14.2% at 180 minutes. There were no significant changes in free fatty acid and lactate concentrations. Mean serum calcium rose slightly but significantly during the treatment period from 2.17 +/- 0.04 to 2.26 +/- 0.03 mean +/- SEM mmol/l. It is concluded that diabetes is not worsened by lithium, at least during short term therapy.

摘要

在6名II型成年起病糖尿病患者中，于服用碳酸锂1周前后（血清锂浓度为0.5 - 1.5 mmol/l），对一份标准的50克碳水化合物早餐的代谢反应进行了3小时的评估。服用锂后，60至180分钟期间血浆葡萄糖反应显著降低，但血浆胰岛素未发生变化。胰岛素/葡萄糖比值在60分钟时下降了17.3%，在180分钟时上升了14.2%。游离脂肪酸和乳酸浓度无显著变化。治疗期间，平均血清钙略有但显著升高，从2.17 +/- 0.04升至2.26 +/- 0.03 mmol/l（均值 +/- 标准误）。结论是，至少在短期治疗期间，锂不会使糖尿病恶化。