Stubbe I, Hansson P, Gustafson A, Nilsson-Ehle P
Metabolism. 1983 Dec;32(12):1120-8. doi: 10.1016/0026-0495(83)90058-6.
Eighteen healthy sedentary males took part in supervised bicycle training for 50 minutes three to five times a week. Twelve subjects (group A) trained for 6 weeks at heavy intensity, and six subjects (group B) trained for 12 weeks at moderate intensity. Maximal oxygen uptake increased by about 20% (P less than 0.01). Body weight and composition as well as diet remained unchanged. After 6 weeks plasma high-density lipoprotein (HDL) cholesterol concentrations had increased by 7% (P less than 0.05) in all subjects. The increase was most marked in group B at 14% (P less than 0.05) compared to 3% in group A (ns). Apolipoprotein AI (apo AI) increased by about 7% in both groups (P less than 0.01). After 12 weeks HDL cholesterol and apo AI levels had almost returned to initial values. Measurements of HDL components showed increases of 6% to 12% in free cholesterol, cholesteryl ester (P less than 0.05), and phospholipid (P less than 0.01); whereas, the minor triglyceride fraction decreased by 20% (P less than 0.01). Zonal ultracentrifugation in four subjects revealed a preferential rise of about 35% in the HDL2 subfraction, increasing the HDL2/HDL3 ratio by about 20%. In parallel, the composition of the lipoprotein classes changed. The protein moiety of all classes, except low-density lipoprotein (LDL), expanded at the expense of the core components cholesteryl ester and triglyceride. Hepatic lipase (HL) activity decreased by 6% (P less than 0.05), and lipoprotein lipase (LPL) activity in adipose tissue increased by about 50% (P less than 0.05) during the first 6 weeks of training, while LPL activity in postheparin plasma and skeletal muscle did not change. The transient rise in HDL cholesterol levels was correlated (P less than 0.05) to the elevation of adipose tissue LPL activity. The alterations in HDL concentration were also related to changes in body composition and diet, especially to an increase in fat intake.
18名健康的久坐男性参加了有监督的自行车训练，每周三到五次，每次50分钟。12名受试者（A组）进行了6周的高强度训练，6名受试者（B组）进行了12周的中等强度训练。最大摄氧量增加了约20%（P<0.01）。体重、身体成分以及饮食保持不变。6周后，所有受试者的血浆高密度脂蛋白（HDL）胆固醇浓度增加了7%（P<0.05）。B组的增加最为显著，为14%（P<0.05），而A组为3%（无统计学意义）。两组的载脂蛋白AI（apo AI）均增加了约7%（P<0.01）。12周后，HDL胆固醇和apo AI水平几乎恢复到初始值。HDL成分的测量显示，游离胆固醇、胆固醇酯（P<0.05）和磷脂（P<0.01）增加了6%至12%；而少量的甘油三酯部分下降了20%（P<0.01）。对4名受试者进行的区带超速离心显示，HDL2亚组分优先升高约35%，使HDL2/HDL3比值增加约20%。同时，脂蛋白类别的组成发生了变化。除低密度脂蛋白（LDL）外，所有类别的蛋白质部分增加，以胆固醇酯和甘油三酯等核心成分减少为代价。在训练的前6周，肝脂酶（HL）活性下降了6%（P<0.05），脂肪组织中的脂蛋白脂酶（LPL）活性增加了约50%（P<0.05），而肝素后血浆和骨骼肌中的LPL活性没有变化。HDL胆固醇水平的短暂升高与脂肪组织LPL活性的升高相关（P<0.05）。HDL浓度的变化也与身体成分和饮食的变化有关，尤其是脂肪摄入量的增加。
