Hespel P, Lijnen P, Fagard R, Van Hoof R, Amery A
Department of Pathophysiology, Catholic University of Leuven, Belgium.
Drugs. 1988;36 Suppl 2:27-32. doi: 10.2165/00003495-198800362-00006.
Cross-sectional studies have demonstrated in the past that endurance-trained persons are characterised by a less atherogenic lipid profile than their sedentary counterparts: the former have clearly higher HDL-cholesterol and lower serum triglyceride concentrations than the latter, and also their LDL-cholesterol and total cholesterol concentrations are slightly lower. In a longitudinal intervention study in previously sedentary men, the effect of moderate short term physical training on the serum lipid profile was investigated. 30 healthy male volunteers were trained for 16 weeks, 3 hours weekly. After training their physical working capacity was increased on average by 29%. This was accompanied by an increment in the HDL-cholesterol fraction of 26%; the relative increase was greater for HDL2-(+32%) than for HDL3-cholesterol(+24%). VLDL-cholesterol was reduced by 21% at the end of the training period. On average, plasma total cholesterol, total triglycerides and LDL-cholesterol were not significantly changed at the end of the training period. Negative associations were, however, found between the training-induced increase in exercise capacity and the concomitant changes in plasma triglycerides and LDL-cholesterol. In conclusion, these longitudinal observations show that short term moderate endurance training improves the serum lipid profile in previously sedentary men.
过去的横断面研究表明，耐力训练者的脂质谱比久坐不动的人更不易致动脉粥样硬化：前者的高密度脂蛋白胆固醇明显高于后者，血清甘油三酯浓度低于后者，其低密度脂蛋白胆固醇和总胆固醇浓度也略低。在一项针对先前久坐不动男性的纵向干预研究中，研究了短期适度体育锻炼对血清脂质谱的影响。30名健康男性志愿者接受了为期16周、每周3小时的训练。训练后，他们的身体工作能力平均提高了29%。与此同时，高密度脂蛋白胆固醇部分增加了26%；高密度脂蛋白2（增加32%）的相对增加幅度大于高密度脂蛋白3胆固醇（增加24%）。训练期结束时，极低密度脂蛋白胆固醇降低了21%。平均而言，训练期结束时血浆总胆固醇、总甘油三酯和低密度脂蛋白胆固醇没有显著变化。然而，在训练引起的运动能力增加与血浆甘油三酯和低密度脂蛋白胆固醇的相应变化之间发现了负相关。总之，这些纵向观察结果表明，短期适度的耐力训练可改善先前久坐不动男性的血清脂质谱。
