Haas I G, Wabl M
Nature. 1983;306(5941):387-9. doi: 10.1038/306387a0.
Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.
前B淋巴细胞及其衍生的杂交瘤在没有轻链（L链）的情况下合成免疫球蛋白重链（IgH）。在代表前B细胞阶段的艾贝尔森病毒转化系18-81中，我们观察到至少一些重链与除轻链之外的一种蛋白质结合。在此我们表明，该蛋白质（我们称之为免疫球蛋白重链结合蛋白，BiP）与游离的IgH非共价结合，但不与与IgL相关的IgH结合。
